Mapping in mice oligodendrocyte cells of the nervous tissue, opened broad prospects for the emergence of effective drug from multiple sclerosis.
The study was conducted by the staff of the Department of biochemistry at the Karolinska Institute. To date, more than two and a half million people worldwide suffer from multiple sclerosis. The disease develops when white blood cells of the immune system attack myelin – the fatty substance of the nerve fibers. This prevents proper transmission of electrical impulses in the body and leads to the development of the disease. Modern methods of treatment of multiple sclerosis are reduced by the inhibition of disease – slowing its development. This approach is inefficient because patients want to get rid of health problems forever, and the existing conditions is impossible.
Thanks to modern research, scientists have created a new theory about the causes of progression, and in this work the important role played by oligodendrocytes. Biochemists assume that these cells are able to participate in the clearing of myelin. The study was conducted using the recently developed technique of single-cell RNA sekvenirovaniya. Owing to this method, the scientists obtained the genetic activity of individual cells. This allowed us to determine the different role played by substances in the body.
This discovery could lead to the creation of reliable drugs for multiple sclerosis. However, to confirm the veracity of the new assumptions more research is needed.