Phthalates cause mutations and damage to sperm, increased frequency of abnormal sperm and DNA damage in the germ cells, especially after chronic exposure, say genetics.
The overall impact of endocrine disruptors, including phthalates, is regarded as one of the causes of reduced sperm count and poorer quality sperm, which can lead to infertility and a higher incidence of congenital malformations of the genital tract. Phthalates are chemicals that are widely used in industry to impart softness and flexibility to plastic products. This article describes the effects of individual phthalates di(2-Ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP); butylbenzyl phthalate (BPD), diethyl phthalate (DEP), Di-isononyl phthalate (DINP) in the male gametes, breeding, and the offspring of animals exposed to. The results of several works showed that the aforementioned phthalates sebastienne, while studies have shown that they have enough anti-androgenic abilities.
Viewed reports in laboratory animals have confirmed that these substances harm the sperm. Phthalates can induce in male gametes mutations, leading to an increase in pre-and postnatal mortality of the offspring and the incidence of congenital malformations, growth retardation, delayed sexual development, shortening of the anogenital distance in males, disturbance of the sex ratio and reducing sperm quality in the F1 generation. The sensitivity of the life stages of mammals to platinum as follows: the fruit — peripubertal adult.
Human studies have shown limited correlation between exposure to phthalates and sperm quality. The concentration of these substances in the biomaterial men at the level from 0.08 to 1.32 mg/kg. Most people pointed out the high level of phthalates in urine and semen quality, however, on the basis of the results of other studies, the impact of the environment on sperm parameters appears to be rather small.